Dr. H Munguba reported in “Cell”. (2026) That somatostatin interneurons in the prefrontal cortex were critical to ketamine’s action and interactions with mu opiate receptors were critical tp maintaining the AD effects.Based on their finding of the centrality of GPCR-mediated signaling within Sst-expressing interneurons in the mPFC, both in driving the antidepressant effects of ketamine and the opposing depressive effects caused by chronic stress, the team used molecular biology tools to identify an ensemble of different GPCRs in the same subtype of neurons.

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