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Treatments
June 4, 2024

Naltrexone Augmented with Prazosin Is Highly Effective for Alcohol Use Disorder

Murray Raskind, of the VA Northwest Mental Illness Research, Education, and Clinical Center, conducted a translational proof-of-concept randomized controlled trial (RCT) of the mu-opioid receptor antagonist, naltrexone, au...
Treatments
June 1, 2024

A Disease-Modifying Drug, Lecanemab, is Now Available for Alzheimer's

C. H. van Dyck from Yale talked about the diagnosis and treatment of Alzheimer’s dementia. -- New brain imaging data have revealed that Lecanemab cannot only highly significantly delay memory decline but also improve PET m...
Treatments
May 31, 2024

Intramuscular versus Intravenous Ketamine for the Management of Treatment-Resistant Depression and Suicidal Ideation

Cristina Albott of the University of Minnesota Medical School reported relatively similar efficacy of intramuscular versus intravenous ketamine for the management of treatment-resistant depression and suicidal ideation in ...
Treatments
May 29, 2024

Lithium Is Unparalleled in It Range of Efficacy in the Mood Disorders

Most clinicians are aware of lithium’s superiority over other mood stabilizers in bipolar illness prophylaxis. New data suggests this might also apply to the atypical antipsychotics. -- Lithium is also not only an effectiv...
Treatments
May 1, 2024

Lithium vs Anticonvulsants Lamotrigine and Valproate on 10 year physical illness

In a study by lars Kessing in (European Neeuropsychopharmcology Volume 84, July 2024, Pages 48-56) on 169,285 patients taking either lithium or the anticonvulsants Lamotrigine (LTG) or Valproate (VPA) for at least 10 years...
Treatments
March 21, 2024

Lithium is Vastly Underutilized in Bipolar Disorder Leading to Premature Death and Disability - We Want You to Help Reverse This Anomalous Trend

We are looking for people who have had a good course of illness with lithium included in their treatment regimen to help spread the word that lithium works extremely well and its side effects are erroneously overestimated....
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Treatments
February 16, 2024

GLP-1s Might Decrease the Incidence of Depression and Anxiety

Lisa O’Mary of WebMD wrote: “People taking a popular type of drug for weight loss or to manage diabetes have a lower likelihood of being newly diagnosed with depression or anxiety, according to an analysis of millions of p...
Treatments
January 10, 2024

Vitamin B6 Plus Lithium Helps Ease Mania Symptoms in Patients With Bipolar Disorder

Daily vitamin B6 (40mg/day), but not B1 (100mg/day), as an adjunctive therapy to lithium was associated with the improvement of mood symptoms in hospitalized patients with bipolar disorder experiencing a manic episode, acc...
Treatments
January 10, 2024

Cannabis and Cannabinoids Don’t Work for Pain or Posttraumatic Stress Disorder

Aaron S. Wolfgang, MD and Charles W. Hoge, MD reviewed data on cannabis in JAMA Psychiatry and found that there were big placebo effects and no evidence for effectiveness of cannabis in military personal. -- This negative ...
Treatments
December 21, 2023

New Data on Extending the Effects of IV Ketamine: Implications for countering the effects of stigma.

John Krystal of Yale U. in an article in Proceedings of the National Academy of Sci. (2023) gave new information about the anatomical and physiological effects of ketamine and about how to extend its effects. Ketamine in a...
Treatments
December 20, 2023

More Data that Long Term Lithium Treatment Does NOT CAUSE RENAL TOXICITY (more than those on valproate).

In a recent meeting, Mark Weiser of Sheba Medical Center analysed data from “from the Clalit Health Services (CHS) database, the largest provider of health insurance in Israel, n=4.8 million, representing over 50% of the I...
Treatments
November 29, 2023

FDA Warns of Potentially Lethal Reaction to Seizure Meds

Megan Brooks reports: -- “The antiseizure drugs levetiracetam (Keppra, Keppra XR, Elepsia XR, Spritam, generic) and clobazam (Onfi, Sympazan, generic) can cause a rare but serious drug hypersensitivity reaction that can be...
Treatments
July 12, 2023

Assets of Exercise

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Ben Goldstein of the University of Toronto gave a plenary talk on the benefits of exercise....
Treatments
July 12, 2023

A Case Report: Good Effect of Psilocybin Even with No Psychedelic Effects

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Marisa Leon-Carlyle reported on a 43 yr. old man with chronic treatment refractory depressi...
Treatments
July 11, 2023

High Response Rate to Psilocybin in Bipolar II Depression

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Scott Aaronson gave 15 medication-free BP II patients (off all medications) 25mg of psilocy...
Treatments
July 11, 2023

Antidepressant Effects of Psilocybin in Unipolar Depression

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Alan Young reported on 233 patients with treatment refractory depression who were given 10m...
Treatments
July 10, 2023

Preliminary Data on Ketogenic Diet

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Georgia Ede gave a talk on the first results of 12 bipolar patients using a ketogenic diet ...
Treatments
July 9, 2023

The Need for Psychotherapy for Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Greg Murray gave a talk on effectiveness of multiple types of psychotherapy for bipolar dis...
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Treatments
July 8, 2023

Positive Effects of Low-Dose Lithium (LDL)

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Rebecca Strawbridge of the Institute of Psychiatry, Psychology & Neuroscience, King’s Colle...
Treatments
July 7, 2023

Patterns of Pharmacotherapy for Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Balwinder Singh of the Mayo Clinic College of Medicine reported on “10,351 individuals from...
Treatments
July 7, 2023

Lumateperone for Bipolar I or Bipolar II Depression: Few Extrapyramidal and Motor Symptoms

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Tobie Escher of Intra-Cellular Therapies, Inc. reported on the excellent tolerability of lu...
Treatments
July 6, 2023

Beneficial Cognitive Effects of Transcranial Infrared Laser Stimulation (TILS) in Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Michael Gentry of The University of Texas At Austin reported on 30 individuals with remitte...
Treatments
July 5, 2023

Intravenous Arketamine As Adjunctive Treatment for Bipolar Depression

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- I.D. Bandeira of Stanford University reported on the feasibility and safety of the (R)-enantiomer of keta...
Treatments
July 4, 2023

Lithium's Diversity of Assets

Editor’s Note: Lithium is vastly underutilized. There is wide spread ignorance about its many assets and misconceptions about its few side effects. Here is an update that should be of interest to potential users, family me...
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Treatments
July 3, 2023

The Systematic Treatment Optimization Program for Early Mania

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- A. Rathseesh and L. Yatham reported on the importance of systematic vigorous treatment of a...