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Biology
June 3, 2024

Accelerated iTBS Treats Bipolar Depression in 5 Days

Yvette Sheline, of the University of Pennsylvania Perelman School of Medicine, reported that 10 intermittent theta burst stimulations (iTBS) per day for 5 days yielded dramatic improvement in patients with bipolar depressi...
Treatments
May 29, 2024

Lithium Is Unparalleled in It Range of Efficacy in the Mood Disorders

Most clinicians are aware of lithium’s superiority over other mood stabilizers in bipolar illness prophylaxis. New data suggests this might also apply to the atypical antipsychotics. -- Lithium is also not only an effectiv...
Treatments
May 1, 2024

Lithium vs Anticonvulsants Lamotrigine and Valproate on 10 year physical illness

In a study by lars Kessing in (European Neeuropsychopharmcology Volume 84, July 2024, Pages 48-56) on 169,285 patients taking either lithium or the anticonvulsants Lamotrigine (LTG) or Valproate (VPA) for at least 10 years...
Biology
February 17, 2024

Bipolar I patient show dramatic reductions in white matter integrity

Thiel et al in Neuropsychopharmacology (2024) reported that “Compared with HC [healthy controls], BD-I patients exhibited lower FA [fractional anisotropy] in widespread clusters (ptfce-FWE?< 0.001), including almost all ma...
Treatments
December 20, 2023

More Data that Long Term Lithium Treatment Does NOT CAUSE RENAL TOXICITY (more than those on valproate).

In a recent meeting, Mark Weiser of Sheba Medical Center analysed data from “from the Clalit Health Services (CHS) database, the largest provider of health insurance in Israel, n=4.8 million, representing over 50% of the I...
Treatments
July 10, 2023

Preliminary Data on Ketogenic Diet

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Georgia Ede gave a talk on the first results of 12 bipolar patients using a ketogenic diet ...
Risk Factors
July 8, 2023

Childhood Bullying and Maltreatment Yield A Worse Course of Bipolar Illness

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Georgina Hosang of Bart’s & The London, Queen Mary’s School of Medicine reported that bully...
Treatments
July 7, 2023

Patterns of Pharmacotherapy for Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Balwinder Singh of the Mayo Clinic College of Medicine reported on “10,351 individuals from...
Treatments
July 7, 2023

Lumateperone for Bipolar I or Bipolar II Depression: Few Extrapyramidal and Motor Symptoms

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Tobie Escher of Intra-Cellular Therapies, Inc. reported on the excellent tolerability of lu...
Biology
July 7, 2023

Both Obesity and Bipolar Disorders in 2249 Individuals Show White Matter Microstructure Abnormalities

Lorielle Dietze of Dalhousie University “obtained body mass index (BMI) and diffusion tensor imaging derived fractional anisotropy (FA) values from 930 individuals with bipolar disorders (BD), and 1319 control individuals ...
Biology
July 6, 2023

Cognitive Function and White Matter Integrity in Individuals With Bipolar Disorder

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- Jennifer McDowell reported that they found “significantly reduced FA (fractional anisotropy) values in 85...
Treatments
July 6, 2023

Beneficial Cognitive Effects of Transcranial Infrared Laser Stimulation (TILS) in Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Michael Gentry of The University of Texas At Austin reported on 30 individuals with remitte...
Treatments
July 5, 2023

Intravenous Arketamine As Adjunctive Treatment for Bipolar Depression

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- I.D. Bandeira of Stanford University reported on the feasibility and safety of the (R)-enantiomer of keta...
Risk Factors
July 3, 2023

Early Antidepressant Use is Associated with Rapid Cycling Bipolar Disorder

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- A.C. Courtes and Jair Soares reported that “Antidepressants were prescribed as the first psychiatry medic...
Public Policy
July 3, 2023

Even Psychotic Mania Does Not Preclude Remarkable Success

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Major (Two Star) General Gregg F. Martin described his lifetime hyperthermia (high energy) ...
Biology
July 3, 2023

Disrupted Circadian Temperature Rhythm in Skin Temperature in Bipolar Mania

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Andrea Stautland of University of Bergen studied the nocturnal temperature of sleeping part...
Treatments
July 3, 2023

“Pharmacotherapy of Bipolar Depression”

Roger McIntyre gave a talk on the “Pharmacotherapy of Bipolar Depression” at the International Society for Bipolar Disorders Conference in Chicago, June 22-25, 2023 -- He pointed out that, contrary to the many approved age...
Biology
July 1, 2023

Higher Brain Temperature in Youth Bipolar Disorder Using a Novel Magnetic Resonance Imaging Approach

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- Ben Goldstein of the University of Toronto reported that “Brain temperature was significantly higher in B...
Biology
February 22, 2023

Sleep Disturbances in Pediatric Bipolar NOS is the Same as in BP I

Gianni Faedda reported in Frontiers in Psychiatry (2012) that decreased need for sleep is as prominent in BP NOS children as in those with BP I. So it appears that with the exception of only brief periods of mania in BP NO...
Childhood
January 25, 2023

Two different subtypes of early onset unspecified bipolar disorder (USBD)

The first subtype is classical BP NOS (Not Otherwise Specified) having all the characteristics of full-blown bipolar disorder except for only having brief durations of mania and responding to conventional treatment. The se...
Treatments
December 14, 2022

Lithium is a Lifesaver in Bipolar Disorder

Batya Swift Yasgur MA, LSW reported in Medscape Medical News on November 28, 2022 that “Mood stabilizers protect against suicide and all-cause mortality in patients with bipolar disorder (BD), including natural mortality, ...
Treatments
May 8, 2020

Fish Oil Monotherapy on Depression in Adolescents at High Risk for Bipolar I Disorder: Ambiguity Persists

Fish oil supplements -- Researcher Robert K. McNamara and colleagues reported in the Journal of Child and Adolescent Psychopharmacology in a 2020 article that 12 weeks of treatment with omega-3 fatty acids in the form of f...
Risk Factors
February 8, 2019

Risk Gene for Bipolar Disorder Implicated in Depressed Behaviors and Abnormal Firing of GABA Neurons

At a 2018 scientific meeting and in a 2017 article in the journal PNAS, researcher Shanshan Zhu and colleagues reported that mice genetically engineered to lack the protein Ankyrin-G in certain neurons showed increases in ...