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Biology
June 3, 2024

Accelerated iTBS Treats Bipolar Depression in 5 Days

Yvette Sheline, of the University of Pennsylvania Perelman School of Medicine, reported that 10 intermittent theta burst stimulations (iTBS) per day for 5 days yielded dramatic improvement in patients with bipolar depressi...
Biology
May 30, 2024

Influence of Childhood Maltreatment on Morphometry and Brain Network Architecture in Bipolar Disorder

Martin Teicher of McLean Hospital, Harvard Medical School, reported on the influence of childhood maltreatment on morphometry and brain network architecture in Bipolar Disorder. -- “Childhood maltreatment (MAL) is common i...
Treatments
May 29, 2024

Lithium Is Unparalleled in It Range of Efficacy in the Mood Disorders

Most clinicians are aware of lithium’s superiority over other mood stabilizers in bipolar illness prophylaxis. New data suggests this might also apply to the atypical antipsychotics. -- Lithium is also not only an effectiv...
Treatments
May 1, 2024

Lithium vs Anticonvulsants Lamotrigine and Valproate on 10 year physical illness

In a study by lars Kessing in (European Neeuropsychopharmcology Volume 84, July 2024, Pages 48-56) on 169,285 patients taking either lithium or the anticonvulsants Lamotrigine (LTG) or Valproate (VPA) for at least 10 years...
Public Policy
March 29, 2024

Quotes from Kay Jamison, PhD, Professor of Psychiatry at the Johns Hopkins School of Medicine

“There’s this notion that mania and depression are uncommon or certainly that mania is uncommon, and that is not true. The bipolar illness spectrum is associated with a lot of very damaging things, most importantly suicide...
Treatments
January 10, 2024

Vitamin B6 Plus Lithium Helps Ease Mania Symptoms in Patients With Bipolar Disorder

Daily vitamin B6 (40mg/day), but not B1 (100mg/day), as an adjunctive therapy to lithium was associated with the improvement of mood symptoms in hospitalized patients with bipolar disorder experiencing a manic episode, acc...
Treatments
January 10, 2024

Cannabis and Cannabinoids Don’t Work for Pain or Posttraumatic Stress Disorder

Aaron S. Wolfgang, MD and Charles W. Hoge, MD reviewed data on cannabis in JAMA Psychiatry and found that there were big placebo effects and no evidence for effectiveness of cannabis in military personal. -- This negative ...
Treatments
December 20, 2023

More Data that Long Term Lithium Treatment Does NOT CAUSE RENAL TOXICITY (more than those on valproate).

In a recent meeting, Mark Weiser of Sheba Medical Center analysed data from “from the Clalit Health Services (CHS) database, the largest provider of health insurance in Israel, n=4.8 million, representing over 50% of the I...
Biology
July 18, 2023

Changes in brain structure in remitted bipolar patients

Macoveanu et al reported in the Journal of Affective Disorders (2023) that compared to controls that remitted bipolar patients had “a decline in total white matter volume over time and they had a larger amygdala volume, bo...
Treatments
July 12, 2023

Assets of Exercise

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Ben Goldstein of the University of Toronto gave a plenary talk on the benefits of exercise....
Treatments
July 11, 2023

High Response Rate to Psilocybin in Bipolar II Depression

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Scott Aaronson gave 15 medication-free BP II patients (off all medications) 25mg of psilocy...
Treatments
July 10, 2023

Preliminary Data on Ketogenic Diet

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Georgia Ede gave a talk on the first results of 12 bipolar patients using a ketogenic diet ...
Biology
July 10, 2023

Metabolic Changes in Brain of Bipolar at Autopsy

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Graeme Preston reported on the brain of autopsied bipolar patients having increases asparta...
Risk Factors
July 8, 2023

Childhood Bullying and Maltreatment Yield A Worse Course of Bipolar Illness

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Georgina Hosang of Bart’s & The London, Queen Mary’s School of Medicine reported that bully...
Treatments
July 7, 2023

Patterns of Pharmacotherapy for Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Balwinder Singh of the Mayo Clinic College of Medicine reported on “10,351 individuals from...
Treatments
July 7, 2023

Lumateperone for Bipolar I or Bipolar II Depression: Few Extrapyramidal and Motor Symptoms

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Tobie Escher of Intra-Cellular Therapies, Inc. reported on the excellent tolerability of lu...
Biology
July 7, 2023

Both Obesity and Bipolar Disorders in 2249 Individuals Show White Matter Microstructure Abnormalities

Lorielle Dietze of Dalhousie University “obtained body mass index (BMI) and diffusion tensor imaging derived fractional anisotropy (FA) values from 930 individuals with bipolar disorders (BD), and 1319 control individuals ...
Biology
July 6, 2023

Cognitive Function and White Matter Integrity in Individuals With Bipolar Disorder

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- Jennifer McDowell reported that they found “significantly reduced FA (fractional anisotropy) values in 85...
Treatments
July 6, 2023

Beneficial Cognitive Effects of Transcranial Infrared Laser Stimulation (TILS) in Bipolar Disorder

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Michael Gentry of The University of Texas At Austin reported on 30 individuals with remitte...
Treatments
July 5, 2023

Intravenous Arketamine As Adjunctive Treatment for Bipolar Depression

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- I.D. Bandeira of Stanford University reported on the feasibility and safety of the (R)-enantiomer of keta...
Treatments
July 3, 2023

The Systematic Treatment Optimization Program for Early Mania

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- A. Rathseesh and L. Yatham reported on the importance of systematic vigorous treatment of a...
Risk Factors
July 3, 2023

Early Antidepressant Use is Associated with Rapid Cycling Bipolar Disorder

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- A.C. Courtes and Jair Soares reported that “Antidepressants were prescribed as the first psychiatry medic...
Public Policy
July 3, 2023

Even Psychotic Mania Does Not Preclude Remarkable Success

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Major (Two Star) General Gregg F. Martin described his lifetime hyperthermia (high energy) ...
Biology
July 3, 2023

Disrupted Circadian Temperature Rhythm in Skin Temperature in Bipolar Mania

Highlights from the International Society for Bipolar Disorders Conference Posters and Presentations, Chicago, June 22-25, 2023 -- Andrea Stautland of University of Bergen studied the nocturnal temperature of sleeping part...
Treatments
July 3, 2023

“Pharmacotherapy of Bipolar Depression”

Roger McIntyre gave a talk on the “Pharmacotherapy of Bipolar Depression” at the International Society for Bipolar Disorders Conference in Chicago, June 22-25, 2023 -- He pointed out that, contrary to the many approved age...