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Biology
July 1, 2023

Higher Brain Temperature in Youth Bipolar Disorder Using a Novel Magnetic Resonance Imaging Approach

Highlights from Posters Presented at the Society of Biological Psychiatry Meeting, April 27-29, 2023 in San Diego -- Ben Goldstein of the University of Toronto reported that “Brain temperature was significantly higher in B...
Biology
February 22, 2023

Sleep Disturbances in Pediatric Bipolar NOS is the Same as in BP I

Gianni Faedda reported in Frontiers in Psychiatry (2012) that decreased need for sleep is as prominent in BP NOS children as in those with BP I. So it appears that with the exception of only brief periods of mania in BP NO...
Treatments
December 14, 2022

Lithium is a Lifesaver in Bipolar Disorder

Batya Swift Yasgur MA, LSW reported in Medscape Medical News on November 28, 2022 that “Mood stabilizers protect against suicide and all-cause mortality in patients with bipolar disorder (BD), including natural mortality, ...
Risk Factors
December 7, 2022

Cannabidiol (CBD) does not make cannabis safer

Amir Englund et al reported in Neuropsychopharmacology in A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios that CBD did not protect against the adverse effect of THC. These includ...
Risk Factors
May 11, 2021

ADHD Common in People with Mood Disorders

In a meta-analysis published in the journal Acta Psychiatrica Scandinavica in 2021, researcher Andrea Sandstrom and colleagues reported that people with mood disorders had a three times higher incidence of attention-defici...
Risk Factors
May 5, 2021

Study Examines Comorbidity of ADHD and Bipolar Disorder

In a 2021 review and meta-analysis in the journal Neuroscience and Biobehavioral Reviews, researcher Carmen Schiweck and colleagues described the comorbidity of attention-deficit hyperactivity disorder (ADHD) and bipolar d...
Biology
April 6, 2021

Insomnia Plays Critical Role in Bipolar Disorder

In a 2021 article in the Journal of Psychiatric Research, researcher Laura Palagini and colleagues reported that insomnia symptoms can affect the course of bipolar illness. In a helpful summary and interview in the Psychia...
Biology
July 7, 2020

White Matter Disturbances in Bipolar Disorder

At the 2020 meeting of the International Society for Bipolar Disorders, researcher Clare Beasley described the cellular and molecular underpinnings of the white matter abnormalities typically seen in children and adults wi...
Risk Factors
October 21, 2019

Comorbid Psychiatric Disorders Impair Response to Psychosocial Treatment in Adolescents with Bipolar Disorder

At the 2019 meeting of the International Society for Bipolar Disorders, researcher Marc J. Weintraub and colleagues followed 145 adolescents with bipolar disorder over a period of two years. The adolescents with comorbid d...
Biology
October 9, 2019

Lithium Reverses Thinning of the Cortex That Occurs in Bipolar Disorder

In a 2018 article in the journal Molecular Psychiatry, researcher Derrek P. Hibar reported findings from the largest study to date of cortical gray matter thickness. Researchers in the ENIGMA Bipolar Disorder Working Group...
Biology
January 30, 2019

Nimodipine Decreases Frontal and Parietal Cortical Activity During Working Memory in Healthy Subjects

At a recent scientific meeting, researcher Kristin Bigos and colleagues described the effects of nimodipine, a treatment for brain hemorrhage, on the brain during working memory tasks. Nimodipine is a dihydropyridine L-typ...
Biology
January 16, 2019

White Matter Abnormalities in Obesity

Researcher Ramiro Reckziegel and colleagues reported at a recent scientific meeting that white matter is abnormal in obese adults with bipolar disorder. In a 2018 article in the journal Schizophrenia Bulletin, Reckziegel r...
Biology
January 14, 2019

White Matter Abnormalities Linked to Irritability in Both Bipolar Disorder and DMDD

At a 2018 scientific meeting, researcher Julia Linke of the National Institute of Mental Health reported that there were white matter tract abnormalities in young people who had irritability associated with either bipolar ...
Risk Factors
January 10, 2018

Adipokines May Be the Link Between Mood Disorders and Obesity

Researchers David J. Bond and Lakshmi Yatham think they may have identified why bipolar disorder and obesity occur so often together. In North America, more than 60% of people with bipolar disorder are overweight or obese,...
Biology
September 29, 2017

Brain Scans Differentiate Suicidal from Non-Suicidal Patients with Bipolar Disorder

People with bipolar disorder are at high risk for suicidal behavior beginning in adolescence and young adulthood. A 2017 study by Jennifer A. Y. Johnston and colleagues in the American Journal of Psychiatry uses several br...
Biology
September 13, 2017

Short Telomeres Associated with Family Risk of Bipolar Disorder

Telomeres are bits of genetic material at the end of each strand of DNA that protect chromosomes as they replicate. Short telomeres have been linked to aging and a variety of medical and psychiatric diseases. Stress and de...
Risk Factors
September 8, 2017

Methylphenidate Does Not Cause Mania When Taken with a Mood Stabilizer

Methylphenidate is an effective treatment for attention-deficit hyperactivity disorder (ADHD). Ritalin may be the most commonly recognized trade name for methylphenidate, but it is also sold under the names Concerta, Daytr...
Biology
April 20, 2017

Specific Regions of Hippocampus Linked to Bipolar Disorder

The hippocampus -- It has been clear for some time that the volume of the hippocampus, a brain region implicated in mood and memory processing, plays a role in bipolar disorder. A 2017 article by researcher Bo Cao and coll...
Biology
December 6, 2016

Certain Types of Inflammation and BMI Predict Depression

At the 2016 meeting of the Society of Biological Psychiatry, researcher Femke Lamers and colleagues presented findings from the Netherlands Study of Depression and Anxiety. The inflammatory markers interleukin-6 and CRP we...
Risk Factors
May 4, 2016

Anxiety, Depression, Unstable Mood, and Low-Level Mania Best Predictors of Bipolar Disorder

Researchers are looking for better ways of predicting whether children at risk for bipolar disorder will go on to develop the illness. A 2015 study by David Axelson and colleagues in the American Journal of Psychiatry repo...
Biology
January 6, 2016

Reduced Cognitive Function and Other Abnormalities in Pediatric Bipolar Disorder

At the 2015 meeting of the International Society for Bipolar Disorders, Ben Goldstein described a study of cognitive dysfunction in pediatric bipolar disorder. Children with bipolar disorder were three years behind in exec...
Biology
April 3, 2015

Gene CACNA1C is Associated with Early-Onset Bipolar Disorder

Several genes have previously been implicated in bipolar illness. In a recent study, researchers at the Mayo Clinic, led by Paul Croarkin, compared variations in three genes (CACNA1C, ANK3, and ODZN) across 69 children age...
Biology
March 24, 2015

Brain Activity Differentiates Youth with Bipolar Disorder from Youth with Unipolar Depression

Both bipolar disorder and unipolar depression often begin in childhood or adolescence, but it can be difficult to distinguish the two using symptoms only. People with bipolar illness may go a decade without receiving a cor...
Risk Factors
February 20, 2013

Cardiovascular Problems in Bipolar Disorder May Begin in Adolescence

Adults with bipolar disorder have higher rates of cardiovascular disease and premature death from cardiovascular illness than the general population. At the 2012 meeting of the American Academy of Child and Adolescent Psyc...
Risk Factors
January 15, 2013

Substance Use Among Canadian Adolescents with Bipolar Disorder: The Critical Need for Intervention and Prevention

At the 2012 meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), Antoinette Scavone presented a poster on correlates of substance use disorders among Canadian adolescents with bipolar disorder. Parti...