Given the high incidence of substance abuse in bipolar disorder, the supplement N-acetylcysteine (NAC) should be considered for use as a prophylactic agent and definitely for those already using substances, including stimulants, alcohol, marijuana, and opiates.

De Felice et al reported in Neuropsychopharmacology (2022) how adolescent THC exposure in a rodent model can induce significant morphological disturbances and glutamatergic signaling abnormalities in the hippocampus. The d...